ATN-161 K-8644 (R) Chemical Name: 4-(5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl)pyridine

Chemical Name: 4-(5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl)pyridine

CAS Number: 1211877-36-9

InChiKey: QFYLTUDRXBNZFQ-UHFFFAOYSA-N

7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV

56(6):813-21

ATN-161 K-8644 (R) Chemical Name: 4-(5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl)pyridineATN 161 is a small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN 161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition of endothelial cell cell interactions, endothelial cell matrix interactions, angiogenesis, and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and