SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-2S These culture conditions do not

These culture conditions do not include xenobiotic supplements

Molecular Weight: 376

OSI-027 shows robust antitumor activity in several different human xenograft models representing various histologies

PubMed PMID: 18594049

as well as the expression of a range of other Hif-1α-dependent genes

SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-2S These culture conditions do notSR9009, CAS No. 1379686 30 2, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~670 nM and REV ERB with EC50 ~800 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9009 alters circadian behavior and the circadian pattern of core clock