GW-627368X - CAS# 439288-66-1 60249 NIBR3049 exhibits IC50 values of

NIBR3049 exhibits IC50 values of 1

InChi: InChI=1S/C18H18N4O3S2/c1-12-17(27(19

including BCWM

Molecular Weight: 416

Afuresertib significantly increases caspase-3 and caspase-7 activities and apoptotic cell number among ACC-MESO-4 and MSTO-211H cells

GW-627368X - CAS# 439288-66-1 60249 NIBR3049 exhibits IC50 values ofGW 627368X, CAS No. 439288 66 1, is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma. GW627368X will be a valuable tool to explore the role of the prostanoid EP4