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Additionally, the combined insulin and GLP-1 mechanism of action may not have the same broad appeal in a market dominated by stand-alone GLP-1 drugs

These patients are seeing endocrinologists or primary care physicians, but many endocrinologists are prescribing the GLP-1 therapies, and theyre very adept at screening because of the concern thats been raised

Do we need to stop it? Jaworski said

Doses are adjusted every couple of weeks based on response, goals and side effects

So there are all these different mechanisms that GLP-1 can have an impact on the broad definition maybe of neuroinflammation

Many people quit taking them within a year or two, often because of cost or gastrointestinal side effects, and lasting success still requires exercise and diet changes