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In dogs, inhibition of NO blunts GHRH-induced GH secretion, suggesting that NO acts by decreasing hypothalamic SS release [82]

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10.1016/j.jaad.2018.08.029 122 TseB

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Raun and colleagues (Eur J Endocrinol, 1998) characterised it as the first growth hormone releasing peptide with selectivity approaching that of GHRH itself, reporting growth hormone release without the accompanying ACTH and cortisol elevation seen with earlier compounds in the class such as GHRP-6 and hexarelin