Dofequidar fumarate - CAS# 153653-30-6 K-779 GSK-429286A

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Dofequidar fumarate - CAS# 153653-30-6 K-779 GSK-429286ADofequidar(MS 209) is a novel quinoline compound, which can reverse P glycoprotein (P gp) mediated MDR. IC50 value: Target: P gpin vitro: MS 209 at 3 microM effectively overcame docetaxel resistance in MDR cancer cells, and this concentration was achieved in blood plasma for > 7 h without serious toxicity . MS 209 restored chemosensitivity of SBC 3 ADM cells to VP 16, ADM, and VCR in a dose dependent manner in vitro . MS 209 strongly reversed drug

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