ENMD-2076 60090 OC 144-093

OC 144-093

Smiles: COC1C2C=COC=2C(OC[C@@H](O)C(C)(C)O)=C2OC(=O)C=CC2=1

6-tetrahydropyridine-3-carbonyl)glycine

Water: 26 mg/mL(59

AG-490 at 30 μM inhibits not only Epo-induced phosphorylation of wild-type JAK2 but also constitutive phosphorylation of the JAK2 V617F mutant

ENMD-2076 60090 OC 144-093ENMD 2076 is an orally active, Aurora A angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD 2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over expressed in human cancers. ENMD 2076 also targets the VEGFR, Flt 3 and FGFR3 kinases which have been