Defactinib HCl - CAS# 1073160-26-5 Catalog No.:M7055-2 the kinase domains of which
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Defactinib HCl - CAS# 1073160-26-5 Catalog No.:M7055-2 the kinase domains of whichDefactinib HCl, CAS No. 1073160 26 5, also known as VS 6063 and PF 04554878, is an orally bioavailable, small molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF 04554878 inhibits FAK, which may prevent the integrin mediated activation of several downstream signal transduction pathways, including ERK, JNK MAPK and PI3K Akt, thus inhibiting tumor cell migration, proliferation and
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