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Muscogiuri G, Verde L, Sulu C, Katsiki N, Hassapidou M, Frias-Toral E, et al

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

D.MaS.LiuJ.CastroB.et al

For example, in humans, it typically takes years to develop visual field loss, and treatment typically starts long time after the onset of disease, whereas in these mice, neurodegeneration starts at 5 W (EAAC1 KO mice) or 3 W (GLAST KO mice) and the treatment was started at the onset of neurodegeneration

10.1016/j.ejmech.2015.08.010 2 BasariaS

10.1016/j.biopha.2019.01.030 23 ChenY