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In diabetic nephropathy, podocyte NOX4derived HO drives podocyte injury and slit-diaphragm defects, thereby promoting albuminuria [345], whereas in diabetic retinopathy PKC-driven and VEGF-driven permeability changes are tightly linked to oxidative stress [346]

CNS target engagement will be assessed by measuring levels of key senescence markers in CSF at baseline and after three months treatment with senolytics