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J., Eirin, A., Kirkland, J

Block et al

The definition of free radicals is uncharged molecules (typically highly reactive and short-lived) having an unpaired valence electron. According to the Pharmacognosy Review , reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. Free radicals can be very harmful, but their production within the body is certainly not abnormal or even entirely bad

doi: 10.1046/j.1365-3024.1996.d01-78.x 164 RiveauGPoulain-GodefroyOPDupreLRemoueFMielcarekNLochtCet al

This antioxidant plays a critical role in: Neutralising harmful free radicals

However, a possible bias exists in which responders benefit from long-term ICI therapy and are therefore exposed to a higher risk of developing irAEs throughout time [22]