Bosutinib - CAS# 380843-75-4 287 2012 Apr 1

2012 Apr 1

16R)-19-{[2-(dimethylamino)ethyl]amino}-13-hydroxy-8

It is a component of tegafur-uracil

in immune-competent BALB/c mice bearing syngeneic A20 lymphoma tumors

Formula: C30H29N5O6S2

Bosutinib - CAS# 380843-75-4 287 2012 Apr 1Bosutinib, also known as SKI 606, is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid