Gamabufotalin Catalog No.:M8396-2 Atypical retinoid 7

Atypical retinoid 7

Formula: C24H24Cl2N4O4

Ahmed Fazly

6-tetramethylphenyl)amino)-N-methylacetamido)piperidin-1-yl)methyl)benzamide

CADTH Canadian Drug Expert Committee Recommendation: Obeticholic Acid (Ocaliva — Intercept Pharmaceuticals Canada): Indication: Primary biliary cholangitis [Internet]

Gamabufotalin Catalog No.:M8396-2 Atypical retinoid 7Gamabufotalin (Gamabufagin), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. IC50 value: Target: in vitro: Gamabufotalin (CS 6) strongly suppressed COX 2 expression by inhibiting the phosphorylation of IKK via targeting the ATP binding site, thereby abrogating NF B binding and p300 recruitment to COX 2 promoter. In addition, CS 6 induced apoptosis by activating the