Nilotinib - CAS# 641571-10-0 ndopril DO3A-t-Bu-ester

DO3A-t-Bu-ester

also know as NMS-P937

RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2

NSC-216666

Formula: C18H22O4

Nilotinib - CAS# 641571-10-0 ndopril DO3A-t-Bu-esterNilotinib, also known as AMN107, is a small molecule tyrosine kinase inhibitor approved for the treatment of imatinib resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr Abl kinase inhibitor that is 10 30 fold more potent than imatinib in inhibiting Bcr Abl tyrosine kinase activity and