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BIX-02188 - CAS# 334949-59-6 Catalog No.:M60430-2S E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

BIX-02188 - CAS# 334949-59-6 Catalog No.:M60430-2S E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Name: BIX-02188 - CAS# 334949-59-6 Catalog No.:M60430-2S E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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BIX-02188 - CAS# 334949-59-6 Catalog No.:M60430-2S E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamideBIX 02188, CAS No. 334949 59 6, is a potent inhibitor of MEK5 (IC50 = 4. 3 nM) with reduced activity towards inhibition of ERK5 and TGFR1 (IC50s = 810 and 1, 800 nM, respectively). Inhibition of MEK5 by BIX 02188 induces apoptosis in cells expressing the oncogenic mutant FLT3 ITD. Product information CAS Number: 334949 59 6 Molecular Weight: 412. 48 Formula: C25H24N4O2 Chemical Name: (Z) 3 (((3 ((dimethylamino)methyl)phenyl)amino)(phenyl)methylene) 2

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Description

E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

but mediated Jak2 ubiquitination

It inhibits 15-PGDH with noncompetitive pattern

CAS Number: 154447-36-6

thus promoting LRP6 phosphorylation and Wnt signaling transduction

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