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Moxonidine Hydrochloride Catalog No.:M8975-10 6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor

Moxonidine Hydrochloride Catalog No.:M8975-10 6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor

Name: Moxonidine Hydrochloride Catalog No.:M8975-10 6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor
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SKU: 96122476149
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SKU: 96122476149

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Moxonidine Hydrochloride Catalog No.:M8975-10 6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitorMoxonidine(BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Target: I1 RMoxonidine is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and 2 AR (adrenergic) agonist; displays 40 fold higher affinity for I1 receptors versus 2 adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: 6. 15 + 0. 14). AGN192403, a selective ligand at I1 R, had no influence

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Description

6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1

Blood Cancer J

Formula: C18H17ClF2N4O2S

36-/m0/s1/i1D3

Epub 2012 Sep 11

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