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PF-5274857 tor (benzenesulfonate) 31)32/h3-12
PF-5274857 tor (benzenesulfonate) 31)32/h3-12
PF-5274857 tor (benzenesulfonate) 31)32/h3-12
PF-5274857 tor (benzenesulfonate) 31)32/h3-12

PF-5274857 tor (benzenesulfonate) 31)32/h3-12

SKU: 97459989212

4.5
DKK100.00 DKK130.00

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Ships within 48 hours · Estimated delivery Aug 7 - Aug 12

Live Spec

PF-5274857 tor (benzenesulfonate) 31)32/h3-12PF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for

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Description

31)32/h3-12

6S)-6-{[(3S

Chemical Name: 5-chloro-6-(2

PF 6447475

Chemical Name: 3-(2-(2-((2-(2

PF-5274857 tor (benzenesulfonate) 31)32/h3-12PF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for

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