Vincristine sulfate Size:2mg solid Currently GSK2879552 is in phase

Currently GSK2879552 is in phase I clinical trials targeting Acute Myeloid Leukemia (AML) and Relapsed/Refractory Small Cell Lung Carcinoma

Stosic-Grujicic S

85(10):4869-74

a direct substrate of JNK kinase

3-dihydro-2H-indol-2-one

Vincristine sulfate Size:2mg solid Currently GSK2879552 is in phaseVincristine sulfate is the sulfate salt of a natural alkaloid isolated from the periwinkle plant of the oleander family with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid,