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Notably, the authors suggested that semaglutide may reduce de novo collagen synthesis without causing degradation of pre-existing collagen fibers [29], implying that semaglutide may not improve existing fibrosis, but it may prevent the initiation and progression of fibrosis, which, however, needs other more focused studies to be definitively demonstrated

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AUC 0-24h , semaglutide and C max,semaglutide were approximately 70% higher when dosed with 50 versus 240 mL water[2]

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