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(2016) found that longer-term GLP-1R agonist treatments may not be useful in the weight loss process as the changes seen after short-term treatment such as improvement of activity deficits in the insula and caudate nucleus in response to palatable food did not persist during the long-term treatment (12 weeks)

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Bone Health Concerns (Osteoporosis) One of the most serious but under-discussed long-term risks of GLP-1 medications is their potential impact on bone health

The pooled estimates derived from the included reviews are depicted in Figure 2 and Supplementary Figure S4