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Those of us in our 40s, 50s, and 60s typically lose about 3-8% of our muscle as a natural part of aging, per decade

M.TheinP.ParsaA.YorgasonJ.LuxfordW.UrrutiaR.et al (2014)

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The underlying molecular mechanism allowing this dysmetabolic dependent effect involves P4HA1 function, an enzyme deputed to collagen biosynthesis and fibril formation [23, 63], in the stromal compartment, putting it under the spotlight as a potential early PDAC biomarker particularly sensitive to metabolic alterations

While almost all newborns with SCD may now be expected to survive to adulthood in medium- to well-resourced countries, 75% or more of neonates with SCD die before they turn five in Sub-Saharan Africa

Without adequate butyrate, these cells literally starve, leading to the breakdown of the tight junction proteins (such as zonulin and occludin) that normally seal the gaps between intestinal cells