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To further elucidate the site selectivity of the pS-MIPs, we performed mouse brain protein lysate spike-in experiments (spiking level: 5 fmol to 2 pmol) with a phosphoserine peptide (SpS: AVP S PPPA pS PR) from the N-terminus of the mature serine protease HtrA2/Omi

The aim of this study is to exploit GSH-responsive AP site capture reagent (AP probe-net), which responses to the elevated glutathione (GSH) levels in the tumor micro-environment (TME), releasing reactive alkoxyamine to trap AP sites and block the APE1-mediated BER for targeted anti-tumor activity against ATC

Dulaglutide utilises a large recombinant fusion protein with Fc fragment for prolonged action, achieving a 5-day half-life with once-weekly dosing [29]

doi: 10.2147/DMSO.S370050 10 CDS BGONC